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Most of them improved some primary outcomes of sexual dysfunction such as lubrication arousal desire or orgasm Pain was the most common secondary outcome evaluated and it became better in two studies including sexual therapy and in one intervention with pelvic floor exercises Tertiary outcomes such as anxiety or depression were rarely examined and they improved with sexual therapy and with OnabotulinumtoxinA CONCLUSION Sexual therapy administration of OnabotulinumtoxinA pelvic floor muscles exercises alone or combined with electrostimulation and the use of clitoral devices could be the most recommended interventions to improve the sexuality in women with multiple sclerosisAim Integrated analysis of genomics epigenomics transcriptomics and clinical information contributes to identify specific molecular subgroups and find novel biomarkers for pancreatic cancer Materials methods The DNA copy number variation the simple nucleotide variation methylation and mRNA data of pancreatic cancer patients were obtained from The Cancer Genome Atlas TCGA Bioactive Compound Library in vitro Four molecular subgroups iC1 iC2 iC3 and iC4 of pancreatic cancer were identified by integrating analysis Results The iC1 subgroup harbors better prognosis higher immune score lesser DNA copy number variation mutations and better genomic stability compared with iC2 iC3 and iC4 subgroups Three new genes GRAP2 ICAM3 and A2ML1 correlated with prognosis were identified Conclusion Integrated multiomics analysis provides fresh insight into molecular classification of pancreatic cancer which may help discover new prognostic biomarkers and reveal the underlying mechanism of pancreatic cancerIntroduction To minimize the radiation exposure of mostly young testicular cancer patients it is essential to find out whether CT could be replaced by magnetic resonance imaging MRI in the staging and followup of the patients In this trial we examined whether abdominal MRI is as effective as computed tomography CT in the detection of retroperitoneal metastases of testicular cancerMaterial and methods This prospective study included 50 patients 46 cases of retroperitoneal metastases and 4 controls without abdominal metastases mean age 33 5 years range 2065 years Imaging of the retroperitoneum was performed using CT and 15 T MRI with diffusion weighted imaging DWI One experienced radiologist reanalyzed all of the examinations without knowledge of clinical information All metastatic or suspicious lymph nodes were noted and measured twodimensionally from axial images Nodal detection and the size of detected nodes on CT and MRI were comparedResults There was no significant difference in the detection of retroperitoneal metastasis between CT and MRI The sensitivity of MRI was 098 There was no statistically significant difference in the sizes of lymph nodes found in CT and MRI and even very small lymph nodes could be detected in MRI as well as in CTConclusion MRI with DWI is as good as CT in detection of retroperitoneal lymph node metastases regardless of lymph node size and it can be used as part of followup of testicular cancer patients instead of ionizing radiation producing imaging methodsPurpose To directly compare an algorithmic external levator resection technique with the choice of intraoperative adjustment to the same technique without intraoperative adjustmentsMethods A sequential controlled prospective comparative cohort study Two cohorts were compared a historical control adjustment and an experimental nonadjustment group Fourteen patients 25 eyelids were in the historical cohort and 15 patients 23 eyelids were in the nonadjustment cohort Primary acquired ptosis patients who met inclusion criteria were considered All patients underwent a standardized external levator resection technique Intraoperative adjustments were performed only in the historical cohort Age followup time surgical time and marginal reflex distance 1 MRD1 were collected Statistical analysis was performed using the MannWhitney U test Statistical significance was p less then 005 Primary and secondary outcome measures were postoperative MRD1 minus goal MRD1 and surgical time respectivelyResults Twentyfive historical eyelids were compared with 23 nonadjusted eyelids The average patient age was 684 years range 1984 and 593 years range 2483 for the adjusted and nonadjusted groups Sixmonth postoperative postoperative minus goal MRD1 was 01 mm 95 CI 0301 and 02 mm 95 0500 p 033 and surgical time was 138 min 95 CI 126151 and 95 min 95 CI 90101 p less then 0001 for the adjusted and nonadjusted cohort respectivelyConclusions The external levator resection utilizing a standardized algorithm approach is an efficacious technique for involutional eyelid ptosis With sound technique this method can be performed without the need for intraoperative adjustment thereby saving operative time and achieving similar resultsLeishmaniasis is a neglected disease caused by the protozoa Leishmania ssp Environmental differences found by the parasites in the vector and the host are translated into cellular stress leading to the production of heat shock proteins Hsp These are molecular chaperones involved in the folding of nascent proteins as well as in the regulation of gene expression signalling events and proteostasis Since Leishmania spp use Hsp90 to trigger important transitions between their different stages of the life cycle this protein family becomes a profitable target in antiparasite drug discovery In this work we implemented a multidisciplinary strategy coupling molecular modelling with in vitro assays to identify small molecules able to inhibit Hsp90 from L braziliensis LbHsp90 Overall we identified some compounds able to kill the promastigote form of the L braziliensis and to inhibit LbHsp90 ATPase activityAim Obstructive sleep apnea syndrome OSAS patients show multiple physiological deficits and several neuropsychological comorbidities The aim of this study was to investigate the eating attitudes in OSAS patientsMaterial and methods Polysomnography records of 157 were performed Eating Attitudes Test EAT Beck Depression Inventory BDI and the Beck Anxiety Inventory BAI were applied to all participantsResults The mean age of the 157 individuals included in the study was 472 114 1876 years and 36 n 56 of the individuals were female and 64 n 101 were male When the patients were ranked according to the severity of OSAS 382 n 60 were severe 204 n 32 were moderate 242 n 38 were mild and 172 n 27 were OSAS negative There was a significant difference in terms of the ageandBMIadjusted EAT score according to OSAS severity p 042 There was a significant difference in the ageandBMIadjusted value of the EAT according to the presence of OSAS p 011 After controlling age and BMI no significant correlation was found between the EAT and the BDI r 0