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including a full collection of progressive jackpots This is a fantastic opportunity to boost your earnings potential and keep yourself entertained for hours RTP Pragmatic Play is one of the leading iGaming providers and provides players with a vast collection of slot games Some of them feature competitive RTPs which allow players to maximize their winnings Many of these games are mobilefriendly which makes them ideal for tablets and smartphones Certain games also come with a bonus round that allows players to earn free spins The companys latest release Gates of Olympus takes players to the realm of the ancient Greek gods where Zeus is in charge of the action This slot game with high volatility features a Pay Anywhere option that rewards players when they land eight or more matching symbols anywhere in the reels The game also offers an Free Spins bonus with multipliers up to 500x your bet Another example of a pragmatic trial is the Home Blood Pressure Management HBPM study which 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have the highest external validity They are typically commissioned by practitioners and policy makers to aid in their decisionmaking They also provide a useful way to identify the causeeffect relationship between an intervention and its outcomes However they should not be used to replace the need for explanation studies The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them Schwartz and Lellouch1 suggested a distinction between explanatory trials which confirm a physiological or clinical hypothesis as well as pragmatic trials which inform the practice and policy decisions They also proposed the framework for pragmatic trials called PRECIS2 This tool attempted to define the characteristics of a pragmatic study including recruitment design and delivery of the intervention as well as the followup There is an encouraging increase in the number of pragmatic trials that have been published A recent Medline search using the words naturalistic and pragmatic restricted to randomised controlled trials RCTs returned 34 articles They are displayed in red on Figure 2 This indicates that the health science community is becoming more sensitive to the subject of pragmatism It is important to keep in mind that the majority of studies were conducted in primarycare settings