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1 to 270 004 Improvements in total score peribronchial thickening and mucous pluggings were significantly correlated with improvement in FEV1 forced expiratory volume in 1 s Treatment with lumacaftorivacaftor was associated with a significant improvement in the total CT score which was mainly related to an improvement in mucous pluggings Treatment with lumacaftorivacaftor was associated with a significant improvement in the total CT score which was mainly related to an improvement in mucous pluggingsThe outbreak of the COVID19 pandemic and the measures taken for tackling it had the potential to lead to deep modifications in the supply of illegal drugs and to impact substance users health and social situation To investigate this we used mixed methods ie quantitative data collected with a brief questionnaire from substance users receiving opioid agonist treatment in a treatment centre in Switzerland N 49 and qualitative data obtained using semistructured phone interviews among a subgroup of participants N 17 We repeated data collection twice over four weeks to investigate trends over time N 51 and 14 at wave 2 Findings consistently showed the limited impact of the COVID19 outbreak on the illegal substance market Over the two waves the supply price and purity of three main illegal substances did not significantly vary Substance use was estimated as usual by most trending toward a decrease The impact of the pandemic on participants social situation and health was appraised as low to medium Nevertheless a minority of participants reported higher impact and multivariate analyses showed a more important impact for those who were female younger and not using multiple substances KU55933 ATM Kinase inhibitor This process was implemented quickly and provided an understanding of the shortterm impact of the pandemic on drug markets and usersAcute myeloid leukemia AML the most common type of leukemia in older adults is a heterogeneous disease that originates from the clonal expansion of undifferentiated hematopoietic progenitor cells These cells present a remarkable variety of genes and proteins with altered expression and function Despite significant advances in understanding the molecular panorama of AML and the development of therapies that target mutations survival has not improved significantly and the therapy standard is still based on highly toxic chemotherapy which includes cytarabine AraC and allogeneic hematopoietic cell transplantation Approximately 60 of AML patients respond favorably to these treatments and go into complete remission however most eventually relapse develop refractory disease or chemoresistance and do not survive for more than five years Therefore drug resistance that initially occurs in leukemic cells primary resistance or that develops during or after treatment acquired resistance has become the main obstacle to AML treatment In this work the main molecules responsible for generating chemoresistance to AraC in AML are discussed as well as some of the newer strategies to overcome it such as the inclusion of molecules that can induce synergistic cytotoxicity with AraC MNKI8e emodin metformin and niclosamide subtoxic concentrations of chemotherapy PD0332991 and potently antineoplastic treatments that do not damage nonmalignant cells heteronemin or hydroxyurea azidothymidineSequence files formats FASTA and FASTQ are commonly used in bioinformatics molecular biology and biochemistry With the advent of nextgeneration sequencing NGS technologies the number of FASTQ datasets produced and analyzed has grown exponentially urging the development of dedicated software to handle parse and manipulate such files efficiently Several bioinformatics packages are available to filter and manipulate FASTA and FASTQ files yet some essential tasks remain poorly supported leaving gaps that any workflow analysis of NGS datasets must fill with custom scripts This can introduce harmful variability and performance bottlenecks in pivotal steps Here we present a suite of tools called SeqFu Sequence Fastx utilities that provides a broad range of commands to perform both common and specialist operations with ease and is designed to be easily implemented in highperformance analytical pipelines SeqFu includes highperformance implementation of algorithms to interleave and deinterleave FASTQ files merge Illumina lanes and perform various quality controls identification of degenerate primers analysis of length statistics extraction of portions of the datasets SeqFu dereplicates sequences from multiple files keeping track of their provenance SeqFu is developed in Nim for highperformance processing is freely available and can be installed with the popular package manager MinicondaThreedimensional feature description for a local surface is a core technology in 3D computer vision Existing descriptors perform poorly in terms of distinctiveness and robustness owing to noise mesh decimation clutter and occlusion in real scenes In this paper we propose a 3D local surface descriptor using pointpair transformation feature histograms PPTFHs to address these challenges The generation process of the PPTFH descriptor consists of three steps First a simple but efficient strategy is introduced to partition the pointpair sets on the local surface into four subsets Then three feature histograms corresponding to each pointpair subset are generated by the pointpair transformation features which are computed using the proposed Darboux frame Finally all the feature histograms of the four subsets are concatenated into a vector to generate the overall PPTFH descriptor The performance of the PPTFH descriptor is evaluated on several popular benchmark datasets and the results demonstrate that the PPTFH descriptor achieves superior performance in terms of descriptiveness and robustness compared with stateoftheart algorithms The benefits of the PPTFH descriptor for 3D surface matching are demonstrated by the results obtained from five benchmark datasets