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Enhanced tumor autophagy favorable in vivo antitumor efficacy and effective systematic immune activation are observed after treatment suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatmentHepatitis C virus represents an important global health issue with 71 million of infected people in the word Nrf2 inhibitor Directacting antivirals are quite new molecules that hit specific Hepatitis C virus proteins useful for viral replication and assembly Notably Directacting antivirals bring to high sustained virological response rates showing also a great safety profile This treatment revolution had an impact on transplantation world in fact the number of liver transplants due to Hepatitis C virusrelated cirrhosis and hepatocellular carcinoma is quickly decreasing Even if this therapy has achieved excellent results in terms of morbility and mortality rates reduction there are some debated issues to consider In the present review the main clinical challenges in everyday management of Hepatitis C virus patients treated with Directacting antivirals and the debated effects of viral clearance metabolic cardiovascular immunologic and neoplastic are discussed The detection of barriers that can preclude the delivery of Hepatitis C virus care is the most complex challenge for the scientific community To obtain the Hepatitis C virus global eradication by 2030 as the World Health Organization has set will be complex and laborious and will need a further multilevel effort Individuals diagnosed with gonorrhea are at elevated risk for HIV Per US Centers for Disease Control and Prevention guideline individuals being evaluated for gonorrhea should be screened for HIV concurrently There is limited information on HIV screening among gonorrheadiagnosed individuals across different health care settings Our objective was to identify potential gaps in HIV screening among gonorrheadiagnosed individuals in Baltimore City Maryland We used Sexually Transmitted Disease Surveillance Network project data collected on a random sample of all gonorrhea diagnoses reported to the health department between April 2015 and April 2019 Individuals with known HIV diagnoses were excluded HIV screening was confirmed through surveys administered to the gonorrheadiagnosing provider HIV screening across groups was assessed using Poisson regression models with robust SEs We examined those with and without recent 12 months sexually transmitted infection STI history separately Among 2830 among individuals at elevated risk for HIV acquisition in Baltimore City particularly among those diagnosed in emergency departmentsurgent care centershospital settings Future work should focus on identifying providerlevel barriers to concurrent HIVSTI screening to inform provider education programsDuring the lockdown phase of the COVID19 pandemic a call not to neglect the continuum of care of patients who present with chronic diseases including pain was made In the field of pain COVID19 had an impact both from a clinical ie the influence of SARSCoV2 infection on pain and organizational ie how patients with chronic pain should be managed in the postCOVID19 era perspective Furthermore patients with chronic pain are also frequently frail subjects affected from multiple comorbidities and hence are at increased risk of infection On these bases how the necessity to continue pain therapy will be pursued in the postCOVID19 era In this paper we comment on the abovementioned topics on the basis of available data and our experience as pain therapists Although blood gas analysis BGA is important for supplemental oxygen titration it is invasive intermittent costly and burdensome for staff We assessed whether the Oxygen Reserve Index ORi a novel pulse oximeterbased index that reflects the partial pressure of oxygen PaOinf2inf could determine the amount of postoperative supplemental oxygen We also evaluated the extent of hyperoxia and hypoxia Fifty patients scheduled to undergo breast surgery were randomly assigned to receive ORibased oxygen group O or conventional postoperative oxygen group C treatments Postoperatively patients were transported to the PostAnesthesia Care Unit PACU and then to general wards In group O oxygen was administered at 4 Lmin in the operation room after extubation and was decreased if the ORi was 000 until a continuous index of 000 was achieved for 30 min in the PACU and wards In group C oxygen was administered at 4 Lmin throughout the evaluation period BGA was performed 1 h after anesthesia induction T0 after extubation T1 before PACU exit T2 and on the first postoperative morning T3 Percutaneous oxygen saturation was measured every two seconds from 9 PM after surgery to 6 AM the next morning The supplemental oxygen amount and PaOinf2inf were significantly lower in group O than group C at T2 15 0530 vs 40 4040 Lmin 1173 268 vs 1700 428 mmHg and T3 10 0530 vs 40 4040 Lmin 1075 165 vs 1571 284 mmHg median interquartile ranges and mean 1 SD P001 No patient exhibited hypoxia Based on our results ORi might be useful to titrate postoperative oxygen supplementation Based on our results ORi might be useful to titrate postoperative oxygen supplementation Upper abdominal wall surgical incisions may lead to a severe postoperative pain Therefore adequate analgesia is important Here we investigate whether the low serratusintercostal interfascial plane block SIPB achieves an effective analgesia considering opioids consumption pain control and recovery quality in upper abdominal surgeries This blinded randomized controlled study was conducted on 102 patients undergoing open upper abdominal wall surgery under general anesthesia All patients who received serratusintercostal plane block at the eighth rib as analgesic technique were included in SIPB group and in control group those who received continuous intravenous morphine analgesia Pain scores in numeric verbal scale NVS and opioids consumption at 0 6 12 24 and 48 hours postoperatively were assessed The quality of the postoperative recovery was evaluated using the QoR15 questionnaire at 24 hours This study showed lower postoperative opioid consumption at 24 hours P00001 417 mg vs