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These results suggest that SmMYB98OE can promote tanshinone and salvianolic acid production The present findings illustrate the exploitation of R2R3MYB in terpenoid and phenolic biosynthesis as well as provide a feasible strategy for improving tanshinone and salvianolic acid contents by MYB proteins in S miltiorrhiza 2020 Production and hosting by Elsevier BV on behalf of Cairo UniversityThe aim of the present study was to test the hypothesis that ribs shape changes in patients with OI are more relevant for respiratory function than thoracic spine shape We used 3D geometric morphometrics to quantify rib cage morphology in OI patients and controls and to investigate its relationship with forced vital capacity FVC and forced expiratory volume in 1 s FEV1 expressed as absolute value and as percentage of predicted value pred Regression analyses on the full sample showed a significant relation between rib shape and FEV1 FVC and FVC pred whereas thoracic spine shape was not related to any parameter Subsequent regression analyses on OI patients confirmed significant relations between dynamic lung volumes and rib shape changes Lower FVC and FEV1 values are identified in OI patients that present more horizontally aligned ribs a greater anteroposterior depth due to extreme transverse curve at rib angles and a strong spine invagination greater asymmetry and a vertically short thoracolumbar spine which is relatively straight in at levels 18 and shows a marked kyphosis in the thoracolumbar transition Our research seems to support that ribs shape is more relevant for ventilator mechanics in OI patients than the spine shape 2019 The Authors Published by Elsevier BV on behalf of Cairo UniversityThe infection caused by methicillinresistant Staphylococcus aureus MRSA is a global threat to public health Vancomycin remains one of the firstline drugs for the treatment of MRSA infections However S aureus isolates with complete resistance to vancomycin have emerged in recent years Vancomycinresistant S aureus VRSA is mediated by a vanA gene cluster which is transferred from vancomycinresistant enterococcus Since the first VRSA isolate was recovered from Michigan USA in 2002 52 VRSA strains have been isolated worldwide In this paper we review the latest progresses in VRSA highlighting its resistance mechanism characteristics of VRSA infections as well as clinical treatments 2019 The Authors Published by Elsevier BV on behalf of Cairo UniversityThis paper numerically retrieves cubicquartic solitons having power law of nonlinearity refractive index read more An improvement of the Adomian decomposition scheme is the adopted algorithm of this work The results are displayed along with the established error analysis 2019 The Authors Published by Elsevier BV on behalf of Cairo UniversityRoads are expensive to develop particularly in challenging environmental conditions and a lack of understanding of the properties of soil can lead to poor design and premature failures contributing to costly maintenance The construction industry is exploring new opportunities involving biological processes and products to modify the structural properties of the in situ material in terms of strength volume stability durability and permeability Through an integrative interdisciplinary approach several microorganisms and other existing bioenzymatic products such as secondary metabolites enzymes endospores and extracellular polymeric substances have been considered as possible alternatives to conventional methods for the development of sustainable road infrastructure Limitations in the current state of technology to developing biobased solutions include microorganism selection and the ability to evaluate derivative components in rapid structural tests that enhance the time to development of proper commercial products This study focused on the testing of fermentation derived components of biological materials in a highthroughput manner using miniaturised structural tests to validate screening and selection methodology The methods tested included resistance to abrasion resistance to erosion water absorption and resistance to compression load Unique miniaturised test equipment was successfully developed using computeraided design CAD and 3D printing technologies Effects were measured to enable the rapid evaluation of a target microorganism and for screening of biological components or fractions Results obtained using a Bacillus isolate reported in the current study exhibit strength characteristics and can potentially be formulated as a product for soil stabilisation This work forms the basis for in vitro selection methodology to enhance development of biobased structural materials for application in the road sector 2019 The Authors Published by Elsevier BV on behalf of Cairo UniversityLately long noncoding lnc RNAs are increasingly appreciated for their involvement in multiple sclerosis MS In inflammation and autoimmunity a role of apoprotein A1 ApoA1 mediated by sphingosine 1phosphate receptors S1PRs was reported However the epigenetic mechanisms regulating these biomolecules and their role in MS remains elusive This case control study investigated the role of ApoA1 sphingosine kinase 1 and 2 SPHK1 2 S1PR1 5 interferonγ IFNγ and interleukin 17 IL17 in MS beside three lncRNA APOA1AS IFNGAS1 and RMRP Expression of SPHKs S1PRs and lncRNAs were measured in 72 relapsingremitting MS patients 37 during relapse and 35 in remission and 28 controls Plasma levels of ApoA1 IFNγ and IL17 were determined The impact of these parameters on MS activity relapse rate and patient disability was assessed APOA1AS IFNGAS1 SPHK1 2 and S1PR5 were upregulated in RRMS patients Differences in ApoA1 SPHK2 and IL17 were observed between relapse and remission Importantly ApoA1 SPHK2 and IL17 were related to activity while S1PR1 and IFNγ were linked to disability though only IFNγ was associated with relapse rate Finally an excellent diagnostic power of IFNγ IL17 SPHK1 and APOA1AS was demonstrated whereas SPHK2 showed promising prognostic power in predicting relapses 2019 The Authors Published by Elsevier BV on behalf of Cairo University