Mobulous Technologies
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Total Articles : 1
https://www.selleckchem.com/screening-libraries.html
The aim of this study was to evaluate the neuromuscular structures at risk during modified anterior minimally invasive plating osteosynthesis technique BelangeroLivani for humeral shaft fractures Eight freshfrozen human specimens ranging from 38 to 82years old were used Specimens were positioned supine with the shoulder in 70 abduction and the forearm in full supination Anterior minimally invasive plating osteosynthesis technique according to BelangeroLivani technique was performed in each specimen Under radioscopic control the plate was introduced in retrograde fashion through the subbrachialis path Anatomical structures were inspected and different anatomical parameters were measured after dissection at the end of the surgical procedures Measurements were performed using a high digital caliper Statistical analysis was performed using the Pearsons correlation coefficient test A p value of 005 was used to define statistical significance There were no macroscopic lesions of myotendinous or neurovascular structures in any specimen The mean distance between the radial nerve to the distal lateral end of the plate was 863mm range 4141383mm The mean total length of the humerus was 32859mm We found a significant direct correlation between the total length of the humerus and both specimen height and weight The modified BelangeroLivani anterior MIPO technique for humeral shaft fractures performed in retrograde fashion is safe and useful without major risk to the soft tissue of the anterior compartment of the arm including the radial nerve in the lateral intermuscular septum Intraoperative dissection avoiding deep lateral retraction on the distal approach minimizes the risk of radial nerve damage Strict surgical planning and appreciation for the anatomic landmarks can reduce the risk of damage to neuromuscular structures Level IV Case series with no comparison group Treatment study Level IV Case series with no comparison group Treatment study Iron overload a state with excessive iron storage in the body is a common complication in thalassemia patients which leads to multiple organ dysfunctions including the bone Iron overloadinduced bone disease is one of the most common and severe complications of thalassemia including osteoporosis Currently osteoporosis is still frequently found in thalassemia even with widely available iron chelation therapy Relevant publications published before December 2019 in PubMed database were reviewed Both preclinical studies and clinical trials were obtained using iron overload thalassemia osteoporosis osteoblast and osteoclast as keywords Increased ROS production is a hallmark of iron overloadinduced impaired bone remodeling At the cellular level oxidative stress affects bone remodeling by both osteoblast inhibition and osteoclast activation via many signaling pathways In thalassemia patients it has been shown that bone resorption was increased while bone formation was concurrently reduced In this review reports on the cellular mechanisms of iron overloadassociated bone remodeling are comprehensively summarized and presented to provide current understanding this pathological condition Moreover current treatments and potential interventions for attenuating bone remodeling in iron overload are also summarized to pave ways for the future discoveries of novel agents that alleviate this condition In this review reports on the cellular mechanisms of iron overloadassociated bone remodeling are comprehensively summarized and presented to provide current understanding this pathological condition Moreover current treatments and potential interventions for attenuating bone remodeling in iron overload are also summarized to pave ways for the future discoveries of novel agents that alleviate this conditionThe vascular adhesion protein1 VAP1 inhibitor ASP8232 reduces albuminuria in patients with type 2 diabetes and chronic kidney disease A mechanismbased model was developed to quantify the effects of ASP8232 on renal markers from a placebocontrolled Phase 2 study in diabetic kidney disease with 12 weeks of ASP8232 treatment The model incorporated the available pharmacokinetic pharmacodynamic plasma VAP1 concentration and activity serum and urine creatinine serum cystatin C albumin excretion rate urinary albumintocreatinine ratio and urine volume information in an integrated manner Compound Library Drugindependent timevarying changes and different drug effects could be quantified for these markers using the model Through simulations this model provided the opportunity to dissect the relationship and longitudinal association between the estimated glomerular filtration rate and albuminuria and to quantify the pharmacological effects of ASP8232 The developed drugindependent model may be useful as a starting point for other compounds affecting the same biomarkers in a similar time scale Temporal muscle thickness TMT has been suggested as a novel biomarker that can represent sarcopenia in head and neck malignancies This study investigated the association of TMT with clinical outcomes in patients with newly diagnosed glioblastoma GBM Using electronic medical records all GBM patients between 2008 and 2018 at Seoul St Marys Hospital were reviewed Total 177 patients met our eligibility criteria The thinner group who had TMT less than the median showed shorter overall survival OS and progressionfree survival PFS than the thicker group who had TMT more than median OS 110 versus 180months p 0001 and PFS 60 versus 110months p 0001 In the multivariate analysis the thinner group had negative associations with OS and PFS OS HR 263 134263 p 0001 and PFS HR 221 134250 p 0002 We also performed propensity score matching between the thinner and thicker groups to minimize the potential bias The thinner group showed shorter OS and PFS OS 135 versus 190months p 0006 and PFS 65 versus 90months p 0028 and had negative associations with OS and PFS than the thicker group OS HR 190 119303 p 0008 and PFS HR 170 107270 p 0026 in matched patients Our findings suggest that TMT can be a useful prognostic biomarker for clinical outcomes in GBM patients Further preclinical and clinical studies could help elucidate this association of sarcopenia with clinical outcomes in GBM patients Our findings suggest that TMT can be a useful prognostic biomarker for clinical outcomes in GBM patients Further preclinical and clinical studies could help elucidate this association of sarcopenia with clinical outcomes in GBM patients