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with other lifestyle programs Together these grounded theorybased efforts may improve engagement with webbased interventions designed to support prostate cancer survivorship Typically webbased consumer health information is considered more beneficial for people with high levels of education and income No evidence shows that equityoriented information offers equal benefits to all This is important for parents of low socioeconomic status SES low levels of education and income and usually a low level of literacy This study is based on a conceptual framework of information outcomes In light of this it aims to compare the perception of the outcomes of webbased parenting information in lowSES mothers with that of other mothers and explore the perspective of lowSES mothers on contextual factors and information needs and behavior associated with these outcomes A participatory mixed methods research was conducted in partnership with academic researchers and Naître et grandir NG editors NG is a magazine website and newsletter that offers trustworthy parenting information on child development education health and wellbeing in a format that is easy to trustworthy webbased consumer health information in a format that is easy to read listen or watch This is the first study comparing perceptions of information outcomes in lowSES mothers with those of other mothers Findings suggest that equityoriented webbased parenting information can offer equal benefits to all including lowSES mothers The short narrative Kate can be quickly read by decision policy makers for example web editors and might encourage them to reach the underserved and provide and assess trustworthy webbased consumer health information in a format that is easy to read listen or watchAdapting to the environment statistics by reducing brain responses to repetitive sensory information is key for efficient information processing Bortezomib Yet the finescale computations that support this adaptive processing in the human brain remain largely unknown Here we capitalise on the submillimetre resolution of ultrahigh field imaging to examine functional magnetic resonance imaging signals across cortical depth and discern competing hypotheses about the brain mechanisms feedforward vs feedback that mediate adaptive processing We demonstrate layerspecific suppressive processing within visual cortex as indicated by stronger BOLD decrease in superficial and middle than deeper layers for gratings that were repeatedly presented at the same orientation Further we show altered functional connectivity for adaptation enhanced feedforward connectivity from V1 to higher visual areas shortrange feedback connectivity between V1 and V2 and longrange feedback occipitoparietal connectivity Our findings provide evidence for a circuit of local recurrent and feedback interactions that mediate rapid brain plasticity for adaptive information processingAverage age and obesity prevalence are increasing globally Both aging and obesity are characterized by profound systemic metabolic and immunologic changes and are cancer risk factors The mechanisms linking age and body weight to cancer are incompletely understood but recent studies have provided evidence that the antitumor immune response is reduced in both conditions while responsiveness to immune checkpoint blockade a form of cancer immunotherapy is paradoxically intact Dietary restriction which promotes health and lifespan may enhance cancer immunity These findings illustrate that the systemic context can impact antitumor immunity and immunotherapy responsiveness Here we review the current knowledge of how age and systemic metabolic state affect the antitumor immune response with an emphasis on CD8 T cells which are key players in antitumor immunity A better understanding of the underlying mechanisms may lead to novel therapies enhancing antitumor immunity in the context of aging or metabolic dysfunctionMuch development has been directed toward improving the performance and automation of spike sorting This continuous development while essential has contributed to an oversaturation of new incompatible tools that hinders rigorous benchmarking and complicates reproducible analysis To address these limitations we developed SpikeInterface a Python framework designed to unify preexisting spike sorting technologies into a single codebase and to facilitate straightforward comparison and adoption of different approaches With a few lines of code researchers can reproducibly run compare and benchmark most modern spike sorting algorithms preprocess postprocess and visualize extracellular datasets validate curate and export sorting outputs and more In this paper we provide an overview of SpikeInterface and with applications to real and simulated datasets demonstrate how it can be utilized to reduce the burden of manual curation and to more comprehensively benchmark automated spike sortersResearch on the neural basis of conscious perception has almost exclusively shown that becoming aware of a stimulus leads to increased neural responses By designing a novel form of perceptual fillingin PFI overlaid with a dynamic texture display we frequencytagged multiple disappearing targets as well as their surroundings We show that in a PFI paradigm the disappearance of a stimulus and subjective invisibility is associated with increases in neural activity as measured with steadystate visually evoked potentials SSVEPs in electroencephalography EEG We also find that this increase correlates with alphaband activity a wellestablished neural measure of attention These findings cast doubt on the direct relationship previously reported between the strength of neural activity and conscious perception at least when measured with current tools such as the SSVEP Instead we conclude that SSVEP strength more closely measures changes in attentionIntroduction Infections with the respiratory pathogen Mycoplasma pneumoniae are often chronic recurrent and resistant persisting after antibiotic treatment M pneumoniae grown on glass forms protective biofilms consistent with a role for biofilms in persistence These biofilms consist of towers of bacteria interspersed with individual adherent cellsHypothesisGap Statement A tissue culture model for M pneumoniae biofilms has not been described or evaluated to address whether growth development and resistance properties are consistent with persistence in the host Moreover it is unclear whether the M pneumoniae cells in the biofilm towers and individual bacterial cells have distinct roles in diseaseAim We evaluated the properties of biofilms of M pneumoniae grown on the immortalized human bronchial epithelial cell line BEAS2B in relation to persistence in the host We observed nucleation of biofilm towers and the disposition of individual cells in culture leading to a model of how tower and individual cells contribute to infection and disease