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0 to the ground truth Regorafenib order SHAP showed that in correct density estimations the algorithm based its decision on fibroglandular and fatty tissue In incorrect estimations other structures such as the pectoral muscle or the heart were included To conclude it is feasible to automatically estimate volumetric breast density on MRI without segmentations and to provide accompanying explanationsTimeresolved microCT is an increasingly powerful technique for studying dynamic processes in materials and structures However it is still difficult to study very fast processes with this technique since fast scanning is typically associated with high image noise levels We present weighted back projection a technique applicable in iterative reconstruction methods using two types of prior knowledge 1 a virtual starting volume resembling the sample for example obtained from a scan before the dynamic process was initiated and 2 knowledge on which regions in the sample are more likely to undergo the dynamic process Therefore processes on which this technique is applicable are preferably occurring within a static grid Weighted back projection has the ability to handle small errors in the prior knowledge while similar 4D microCT techniques require the prior knowledge to be exactly correct It incorporates the prior knowledge within the reconstruction by using a weight volume representing for each voxel its probability of undergoing the dynamic process Qualitative analysis on a sparse subset of projection data from a real microCT experiment indicates that this method requires significantly fewer projection angles to converge to a correct volume This can lead to an improved temporal resolutionIn facetoface communication audiovisual AV stimuli can be fused combined or perceived as mismatching While the left superior temporal sulcus STS is presumably the locus of AV integration the process leading to combination is unknown Based on previous modelling work we hypothesize that combination results from a complex dynamic originating in a failure to integrate AV inputs followed by a reconstruction of the most plausible AV sequence In two different behavioural tasks and one MEG experiment we observed that combination is more time demanding than fusion Using timesourceresolved human MEG analyses with linear and dynamic causal models we show that both fusion and combination involve early detection of AV incongruence in the STS whereas combination is further associated with enhanced activity of AV asynchronysensitive regions auditory and inferior frontal cortices Based on neural signal decoding we finally show that only combination can be decoded from the IFG activity and that combination is decoded later than fusion in the STS These results indicate that the AV speech integration outcome primarily depends on whether the STS converges or not onto an existing multimodal syllable representation and that combination results from subsequent temporal processing presumably the offline reordering of incongruent AV stimuliPancreatic diseases such as pancreatitis type 1 diabetes and pancreatic cancer impose substantial healthcare costs and contribute to marked morbidity and mortality Recent studies have suggested a link between gut microbiota dysbiosis and pancreatic diseases however the potential roles and mechanisms of action of gut microbiota in pancreatic diseases remain to be fully elucidated In this review we summarize the evidence that supports relationship between alterations of gut microbiota and development of pancreatic diseases and discuss the potential molecular mechanisms of gut microbiota dysbiosis in the pathogenesis of pancreatic diseases We also propose current strategies toward gut microbiota to advance a developing research field that has clinical potential to reduce the cost of pancreatic diseasesAntibiotic resistance became an increasing risk for population health threatening our ability to fight infectious diseases The objective of this study was to evaluate the activity of laser irradiated thioridazine TZ against clinicallyrelevant bacteria in view to fight antibiotic resistance TZ in ultrapure water solutions was irradiated 1240 min with 266 nm pulsed laser radiation Irradiated solutions were characterized by UVVis and FTIR absorption spectroscopy thin layer chromatography laserinduced fluorescence and dynamic surface tension measurements Molecular docking studies were made to evaluate the molecular mechanisms of photoproducts action against Staphylococcus aureus and MRSA More general solutions were evaluated for their antimicrobial and efflux inhibitory activity against a panel of bacteria of clinical relevance We observed an enhanced antimicrobial activity of TZ photoproducts against Grampositive bacteria This was higher than ciprofloxacin effects for methicillin and ciprofloxacinresistant Staphylococcus aureus Molecular docking showed the Penicillinbinding proteins PBP3 and PBP2a inhibition by sulforidazine as a possible mechanism of action against Staphylococcus aureus and MRSA strains respectively Irradiated TZ reveals possible advantages in the treatment of infectious diseases produced by antibioticresistant Grampositive bacteria TZ repurposing and its photoproducts obtained by laser irradiation show accelerated and lowcosts of development if compared to chemical synthesisT cells expressing the cutaneous lymphocyte antigen CLA mediate pathogenic inflammation in atopic dermatitis AD The molecular alterations contributing to their dysregulation remain unclear With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations CD4 CD4CD45RA naïve CD4CLA and CD8 from adult AD patients and healthy controls HC Skin homing CD4CLA T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC p less then 005 Reduced DNA methylation levels in the upstream region of the interleukin13 gene IL13 in CD4CLA T cells from AD patients correlated with increased IL13 mRNA expression in these cells Sixteen miRNAs showed differential expression in CD4CLA T cells from AD patients targeting genes in 202 biological processes p less then 005 An integrated network analysis of miRNAs and CpG sites identified two communities of strongly interconnected regulatory elements with strong antagonistic behaviours that recapitulated the differences between AD patients and HC